Learning Objectives
- Describe the absorption, transport and storage of iron
- Describe the role of hepcidin in the regulation of iron homeostasis
- Describe the changes in haematological parameters which occur in iron deficiency
- Interpret an iron panel and distinguish iron deficiency from inflammatory anaemias
- Evaluation and investigation of iron deficiency
- Oral iron supplementation
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Question 1 of 10
1. Question
1 point(s)A 68-year-old male presents to your clinic with a 6-month history of worsening fatigue and dyspnoea on exertion. He has no other past medical history of note and takes no regular medication. On examination, you notice conjunctival pallor. The lungs are clear and there is no pedal oedema.
What is the most important history to specifically seek?
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Question 2 of 10
2. Question
1 point(s)Initial investigations show:
RBC 3.25×1012/L (4.00-5.20)
Haemoglobin 7.2 g/dL (13.1-16.6)
MCV 61fL (83.0-95.5)
RDW 19.0% (10.9-14.3)
Platelets 568×109/L (164-387)
WBC 7.8×109/L (3.84-10.01)What investigation should you order next?
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Question 3 of 10
3. Question
1 point(s)You order iron studies.
TIBC = total iron binding capacity
Which of the following best describes the pattern seen in iron deficiency anaemia?
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Question 4 of 10
4. Question
1 point(s)Which of the following describes inflammatory anaemia correctly?
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Question 5 of 10
5. Question
1 point(s)Where is iron absorbed?
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Question 6 of 10
6. Question
1 point(s)Which of the following describes laboratory tests of iron balance correctly?
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Question 7 of 10
7. Question
1 point(s)Based on the iron panel, you refer him for a colonoscopy and he is diagnosed with colorectal cancer. He undergoes curative surgery and is recovering post-operatively.
How would you treat his iron deficiency anaemia?
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Question 8 of 10
8. Question
1 point(s)The patient is started on oral iron therapy. 2 months later, he attends for review. His FBC shows:
Haemoglobin 8.2 g/dL (13.1-16.6)
MCV 63fL (83.0-95.5)
RDW 18.0% (10.9-14.3)
Platelets 428×109/L (164-387)
WBC 7.8×109/L (3.84-10.01)What is the expected rate of rise in haemoglobin in response to oral iron?
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Question 9 of 10
9. Question
1 point(s)What is the most likely reason for his sub-optimal response to treatment?
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Question 10 of 10
10. Question
1 point(s)What is the most likely reason for his sub-optimal response to treatment?
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