If blood group O has been given, blood of the patient’s own ABO group should be given as soon as it has been determined.
Once the blood volume transfused in 24hr period is equivalent to one blood volume (8-10 units for adults, children 80-100ml/kg), ABO/RhD compatible blood can be supplied without the need for a serological cross-match.
Antigen-negative blood should be selected for patients with clinically-significant alloantibodies, but if demand oustrips supply, provision of untyped blood may be necessary.
If FFP or platelets are required and the blood group is unknown, group A should be issued (<3% of group A donors have high titre anti-B).
For platelet components, if a patient is RhD negative and is a female of child-bearing age or a child, then RhD negative platelets should be given. If RhD positive platelets are given, RhD immune globulin is required.
Non-UK plasma (methylene blue-treated FFP, solvent detergent-treated FFP) must be used for all patients born on or after 1 Jan 1996, to reduce the risk of vCJD transmission.
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