Hypoplastic MDS
Hypoplastic MDS accounts for about 10% of all MDS cases. It is characterized by a bone marrow that is hypocellular for age.
Some dysplastic features may be noted, however may not be that florid and the diagnosis may be difficult to differentiate from aplastic anaemia.
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Blood film of a patient with hypoplastic MDS. Note the profound cytopenia. There is a dimorphic RBC picture suggestive of recent transfusion. Dysplastic features are scant.
Blood Film Features:
- Profound cytopenias
- Cytopenias with dysplasia (see MDS overview page for specific features)
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Bone marrow aspirate of a patient with hypoplastic MDS. Very hypocellular marrow with hypocellular cell trials.
Bone Marrow Features:
- Hypocellular bone marrow for age
- Dysplastic features (see MDS overview page for specific features): most common dysplastic micromegakaryocytes
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