FRCPath Haematology Part 2: Morphology RBC Morphology Overview Stomatocytes

Stomatocytes are RBCs with a slit-like area of central pallor. They result from a decreased surface area to volume ratio in RBCs.

Causes:

  • Hereditary stomatocytosis
  • Southeast Asian ovalocytosis
  • Hereditary phytosterolaemia 
  • Liver disease
  • Hydroxyurea therapy
  • Myelodysplastic syndrome
Stomatocytes. Peripheral blood film from a patient with Southeast Asian ovalocytosis, showing numerous stomatocytes. These are oval-shaped cells with a linear, slit-like central pallor.
Peripheral blood film from a patient with Southeast Asian ovalocytosis, showing numerous stomatocytes. These are oval-shaped cells with a linear, slit-like central pallor.
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