FRCPath Haematology Part 2: Morphology RBC Morphology Overview Anisopoikilocytosis

Anisocytosis – cells of different sizes

Poikilocytosis – cells of different shapes

  • Non-specific if mild
  • Myelofibrosis
  • Congenital and acquired dyserythropoietic anaemias
  • Hereditary pyropoikilocytosis
  • HbH disease
Anisopoikilocytosis. Peripheral blood film showing anisopoikilocytosis.
Peripheral blood film from a patient with myelodysplastic syndrome with single lineage dysplasia, showing marked anisopoikilocytosis. The red cells are of varying shapes and sizes.
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